Package: SPINA 5.1.0

SPINA: Structure Parameter Inference Approach

SPINA (Structure Parameter Inference Approach) is a methodology to calculate constant structure parameters of endocrine homeostatic systems from steady-state hormone and metabolite concentrations. Methods and equations for thyroid homeostasis (SPINA Thyr) have been described in Dietrich et al. (2012) <doi:10.1155/2012/351864> and Dietrich et al. (2016) <doi:10.3389/fendo.2016.00057>, and for glucose homeostasis (SPINA Carb) in Dietrich et al. (2022) <doi:10.1038/s41598-022-22531-3> and Dietrich et al. (2024) <doi:10.1111/1753-0407.13525>.

Authors:Johannes W. Dietrich [aut, cph, cre], Eleni Karamitrou [ctb], Bernhard O. Boehm [ctb]

SPINA_5.1.0.tar.gz
SPINA_5.1.0.zip(r-4.7-any)SPINA_5.1.0.zip(r-4.6-any)SPINA_5.1.0.zip(r-4.5-any)
SPINA_5.1.0.tgz(r-4.6-any)SPINA_5.1.0.tgz(r-4.5-any)
SPINA_5.1.0.tar.gz(r-4.7-any)SPINA_5.1.0.tar.gz(r-4.6-any)
SPINA_5.1.0.tgz(r-4.6-emscripten)
manual.pdf |manual.html✨
DESCRIPTION
card.svg |card.png
SPINA/json (API)

# Install 'SPINA' in R:

install.packages('SPINA', repos = c('https://jwdietrich21.r-universe.dev', 'https://cloud.r-project.org'))

Datasets:

Pilo - Data for SPINA
Vellore - Data for SPINA

On CRAN:

This package does not link to any Github/Gitlab/R-forge repository. No issue tracker or development information is available.

3.35 score 15 scripts 411 downloads 3 mentions 20 exports 0 dependencies

Last updated from:99b38818fa. Checks:9 OK. Indexed: yes.

Target	Result	Time
linux-devel	OK	101
source / vignettes	OK	176
linux-release	OK	104
macos-release	OK	142
macos-oldrel	OK	167
windows-devel	OK	71
windows-release	OK	67
windows-oldrel	OK	75
wasm-release	OK	78

Exports:estimated.GD estimated.GDTT estimated.GT estimated.GTT estimated.sGD estimated.sTSHI estimated.TSHI estimated.TTSI HOMA.Beta HOMA.IR HOMA.IS QUICKI SPINA.DI SPINA.GBeta SPINA.GD SPINA.GDTT SPINA.GR SPINA.GT SPINA.GTT SPINA.sGD

Dependencies:

Handbook and Reference for SPINA

Rendered fromSPINA_HandbookReference.Rmdusingknitr::rmarkdown

Last update: 2026-09-17
Started: 2026-09-17

Help page	Topics
Calculated step-up deiodinase activity (SPINA-GD)	estimated.GD
Calculated step-up deiodinase activity, based on total T4 and T3 (SPINA-GDTT)	estimated.GDTT
Calculated thyroid's secretory capacity (SPINA-GT)	estimated.GT
Calculated thyroid's secretory capacity, based on total T4 (SPINA-GTT)	estimated.GTT
Calculated standardised step-up deiodinase activity (SPINA-sGD)	estimated.sGD
Standardised Jostel's TSH index (sTSHI, sJTI)	estimated.sTSHI
Jostel's TSH index (TSHI, JTI)	estimated.TSHI
Thyrotroph thyroid hormone sensitivity index (TTSI)	estimated.TTSI
Homeostasis model assessment: beta-cell function (HOMA-Beta)	HOMA.Beta
Homeostasis model assessment: insulin resistance (HOMA-IR)	HOMA.IR
Homeostasis model assessment: insulin sensitivity (HOMA-IS)	HOMA.IS
Data for SPINA	Pilo
Quantitative insulin-sensitivity check index (QUICKI)	QUICKI
Static disposition index (SPINA-DI)	SPINA.DI
Calculated secretory capacity of pancreatic beta cells (SPINA-GBeta)	SPINA.GBeta
Calculated step-up deiodinase activity (SPINA-GD)	SPINA.GD
Calculated step-up deiodinase activity, based on total T4 and T3 (SPINA-GDTT)	SPINA.GDTT
Calculated insulin receptor gain (SPINA-GR)	SPINA.GR
Calculated thyroid's secretory capacity (SPINA-GT)	SPINA.GT
Calculated thyroid's secretory capacity, based on total T4 (SPINA-GTT)	SPINA.GTT
Calculated standardised step-up deiodinase activity (SPINA-sGD)	SPINA.sGD
Data for SPINA	Vellore

Package: SPINA 5.1.0

SPINA: Structure Parameter Inference Approach

Citation

Readme and manuals

Help Manual

Usage by other packages (reverse dependencies)